Targeting mitochondrial RNA polymerase in acute myeloid leukemia

Acute myeloid leukemia (AML) cells have high oxidative phosphorylation and mitochondrial mass and low respiratory chain spare reserve capacity. We reasoned that targeting the mitochondrial RNA polymerase (POLRMT), which indirectly controls oxidative phosphorylation, represents a therapeutic strategy...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Bralha, Fernando N., Liyanage, Sanduni U., Hurren, Rose, Wang, Xiaoming, Son, Meong Hi, Fung, Thomas A., Chingcuanco, Francine B., Tung, Aveline Y. W., Andreazza, Ana C., Psarianos, Pamela, Schimmer, Aaron D., Salmena, Leonardo, Laposa, Rebecca R.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741925/
https://ncbi.nlm.nih.gov/pubmed/26484416
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