Targeting mitochondrial RNA polymerase in acute myeloid leukemia

Acute myeloid leukemia (AML) cells have high oxidative phosphorylation and mitochondrial mass and low respiratory chain spare reserve capacity. We reasoned that targeting the mitochondrial RNA polymerase (POLRMT), which indirectly controls oxidative phosphorylation, represents a therapeutic strategy...

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Publicat a:Oncotarget
Autors principals: Bralha, Fernando N., Liyanage, Sanduni U., Hurren, Rose, Wang, Xiaoming, Son, Meong Hi, Fung, Thomas A., Chingcuanco, Francine B., Tung, Aveline Y. W., Andreazza, Ana C., Psarianos, Pamela, Schimmer, Aaron D., Salmena, Leonardo, Laposa, Rebecca R.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741925/
https://ncbi.nlm.nih.gov/pubmed/26484416
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