HER2-specific immunoligands engaging NKp30 or NKp80 trigger NK-cell-mediated lysis of tumor cells and enhance antibody-dependent cell-mediated cytotoxicity

NK cells detect tumors through activating surface receptors, which bind self-antigens that are frequently expressed upon malignant transformation. To increase the recognition of tumor cells, the extracellular domains of ligands of the activating NK cell receptors NKp30, NKp80 and DNAM-1 (i.e. B7-H6,...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Peipp, Matthias, Derer, Stefanie, Lohse, Stefan, Staudinger, Matthias, Klausz, Katja, Valerius, Thomas, Gramatzki, Martin, Kellner, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741660/
https://ncbi.nlm.nih.gov/pubmed/26392331
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