Enhancing natural killer cell-mediated lysis of lymphoma cells by combining therapeutic antibodies with CD20-specific immunoligands engaging NKG2D or NKp30

Antibody-dependent cell-mediated cytotoxicity (ADCC) mediated through the IgG Fc receptor FcγRIIIa represents a major effector function of many therapeutic antibodies. In an attempt to further enhance natural killer (NK) cell-mediated ADCC, we combined therapeutic antibodies against CD20 and CD38 wi...

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Vydáno v:Oncoimmunology
Hlavní autoři: Kellner, Christian, Günther, Andreas, Humpe, Andreas, Repp, Roland, Klausz, Katja, Derer, Stefanie, Valerius, Thomas, Ritgen, Matthias, Brüggemann, Monika, van de Winkel, Jan GJ, Parren, Paul WHI, Kneba, Michael, Gramatzki, Martin, Peipp, Matthias
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2015
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760288/
https://ncbi.nlm.nih.gov/pubmed/26942070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1058459
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