Affinity Maturation of B7-H6 Translates into Enhanced NK Cell–Mediated Tumor Cell Lysis and Improved Proinflammatory Cytokine Release of Bispecific Immunoligands via NKp30 Engagement

Activating NK cell receptors represent promising target structures to elicit potent antitumor immune responses. In this study, novel immunoligands were generated that bridge the activating NK cell receptor NKp30 on NK cells with epidermal growth factor receptor (EGFR) on tumor cells in a bispecific...

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Pubblicato in:J Immunol
Autori principali: Pekar, Lukas, Klausz, Katja, Busch, Michael, Valldorf, Bernhard, Kolmar, Harald, Wesch, Daniela, Oberg, Hans-Heinrich, Krohn, Steffen, Boje, Ammelie Svea, Gehlert, Carina Lynn, Toleikis, Lars, Krah, Simon, Gupta, Tushar, Rabinovich, Brian, Zielonka, Stefan, Peipp, Matthias
Natura: Artigo
Lingua:Inglês
Pubblicazione: AAI 2021
Soggetti:
Novel Immunological Methods
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7750860/
https://ncbi.nlm.nih.gov/pubmed/33268483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2001004
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