Increasing FcγRIIa affinity of an FcγRIII-optimized anti-EGFR antibody restores neutrophil-mediated cytotoxicity

Antibody-dependent cell-mediated cytotoxicity (ADCC) has been suggested as an essential mechanism for the in vivo activity of cetuximab, an epidermal growth factor receptor (EGFR)-targeting therapeutic antibody. Thus, enhancing the affinity of human IgG1 antibodies to natural killer (NK) cell-expres...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Derer, Stefanie, Glorius, Pia, Schlaeth, Martin, Lohse, Stefan, Klausz, Katja, Muchhal, Umesh, Desjarlais, John R, Humpe, Andreas, Valerius, Thomas, Peipp, Matthias
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2014
Schlagworte:
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984330/
https://ncbi.nlm.nih.gov/pubmed/24492248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.27457
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