CDK1 phosphorylation of TAZ in mitosis inhibits its oncogenic activity

The transcriptional co-activator with PDZ-binding motif (TAZ) is a downstream effector of the Hippo tumor suppressor pathway, which plays important roles in cancer and stem cell biology. Hippo signaling inactivates TAZ through phosphorylation (mainly at S89). In the current study, we define a new la...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Zhang, Lin, Chen, Xingcheng, Stauffer, Seth, Yang, Shuping, Chen, Yuanhong, Dong, Jixin
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741614/
https://ncbi.nlm.nih.gov/pubmed/26375055
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