Oncoprotein YAP Regulates the Spindle Checkpoint Activation in a Mitotic Phosphorylation-dependent Manner through Up-regulation of BubR1

The transcriptional co-activator YAP (Yes-associated protein) functions as an oncogene; however, it is largely unclear how YAP exerts its oncogenic role. In this study, we further explored the functional significance of YAP and its mitotic phosphorylation in the spindle checkpoint. We found that the...

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Udgivet i:J Biol Chem
Main Authors: Yang, Shuping, Zhang, Lin, Chen, Xingcheng, Chen, Yuanhong, Dong, Jixin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358258/
https://ncbi.nlm.nih.gov/pubmed/25605730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.624411
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