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Cyclin-dependent kinase 1 (CDK1)-mediated mitotic phosphorylation of the transcriptional co-repressor Vgll4 inhibits its tumor-suppressing activity

The Hippo pathway is an evolutionarily conserved signaling pathway that plays important roles in stem cell biology, tissue homeostasis, and cancer development. Vestigial-like 4 (Vgll4) functions as a transcriptional co-repressor in the Hippo-Yes-associated protein (YAP) pathway. Vgll4 inhibits cell...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Zeng, Yongji, Stauffer, Seth, Zhou, Jiuli, Chen, Xingcheng, Chen, Yuanhong, Dong, Jixin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5592678/
https://ncbi.nlm.nih.gov/pubmed/28739871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.796284
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