Arenobufagin intercalates with DNA leading to G(2) cell cycle arrest via ATM/ATR pathway

Arenobufagin, a representative bufadienolide, is the major active component in the traditional Chinese medicine Chan'su. It possesses significant antineoplastic activity in vitro. Although bufadienolide has been found to disrupt the cell cycle, the underlying mechanisms of this disruption are n...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Deng, Li-Juan, Peng, Qun-Long, Wang, Long-Hai, Xu, Jun, Liu, Jun-Shan, Li, Ying-Jie, Zhuo, Zhen-Jian, Bai, Liang-Liang, Hu, Li-Ping, Chen, Wei-Min, Ye, Wen-Cai, Zhang, Dong-Mei
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741450/
https://ncbi.nlm.nih.gov/pubmed/26485758
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