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Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

A Cre/lox-conditional mouse line was generated to evaluate the role of ATR in checkpoint responses to ionizing radiation (IR) and stalled DNA replication. We demonstrate that after IR treatment, ATR and ATM each contribute to early delay in M-phase entry but that ATR regulates a majority of the late...

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Detalhes bibliográficos
Main Authors: Brown, Eric J., Baltimore, David
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC196009/
https://ncbi.nlm.nih.gov/pubmed/12629044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1067403
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