Mcl-1 deficiency results in peri-implantation embryonic lethality

We disrupted the Mcl-1 locus in murine ES cells to determine the developmental roles of this Bcl-2 family member. Deletion of Mcl-1 resulted in peri-implantation embryonic lethality. Mcl-1(−/−) embryos do not implant in utero, but could be recovered at E3.5–4.0. Null blastocysts failed to hatch or a...

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Bibliografiska uppgifter
Huvudupphovsmän: Rinkenberger, Julie L., Horning, Susan, Klocke, Barbara, Roth, Kevin, Korsmeyer, Stanley J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2000
Ämnen:
Research Communication
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC316347/
https://ncbi.nlm.nih.gov/pubmed/10640272
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