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Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

Inheritance of an inactivated form of the VHL tumor suppressor gene predisposes patients to develop von Hippel–Lindau disease, and somatic VHL inactivation is an early genetic event leading to the development of sporadic renal cell carcinoma. The VHL gene was disrupted by targeted homologous recombi...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Gnarra, James R., Ward, Jerrold M., Porter, Forbes D., Wagner, Joseph R., Devor, Deborah E., Grinberg, Alex, Emmert-Buck, Michael R., Westphal, Heiner, Klausner, Richard D., Linehan, W. Marston
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 1997
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23053/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9256442/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.17.9102
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