Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

Inheritance of an inactivated form of the VHL tumor suppressor gene predisposes patients to develop von Hippel–Lindau disease, and somatic VHL inactivation is an early genetic event leading to the development of sporadic renal cell carcinoma. The VHL gene was disrupted by targeted homologous recombi...

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Autors principals: Gnarra, James R., Ward, Jerrold M., Porter, Forbes D., Wagner, Joseph R., Devor, Deborah E., Grinberg, Alex, Emmert-Buck, Michael R., Westphal, Heiner, Klausner, Richard D., Linehan, W. Marston
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1997
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC23053/
https://ncbi.nlm.nih.gov/pubmed/9256442
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