Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

Inheritance of an inactivated form of the VHL tumor suppressor gene predisposes patients to develop von Hippel–Lindau disease, and somatic VHL inactivation is an early genetic event leading to the development of sporadic renal cell carcinoma. The VHL gene was disrupted by targeted homologous recombi...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Gnarra, James R., Ward, Jerrold M., Porter, Forbes D., Wagner, Joseph R., Devor, Deborah E., Grinberg, Alex, Emmert-Buck, Michael R., Westphal, Heiner, Klausner, Richard D., Linehan, W. Marston
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1997
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23053/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9256442/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.17.9102
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