The Absence of Mitochondrial Thioredoxin 2 Causes Massive Apoptosis, Exencephaly, and Early Embryonic Lethality in Homozygous Mice

Thioredoxin 2 (Trx-2) is a small redox protein containing the thioredoxin active site Trp-Cys-Gly-Pro-Cys that is localized to the mitochondria by a mitochondrial leader sequence and encoded by a nuclear gene (Trx-2). Trx-2 plays an important role in cell viability and the regulation of apoptosis in...

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Detalhes bibliográficos
Main Authors: Nonn, Larisa, Williams, Ryan R., Erickson, Robert P., Powis, Garth
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC140716/
https://ncbi.nlm.nih.gov/pubmed/12529397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.3.916-922.2003
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