The Absence of Mitochondrial Thioredoxin 2 Causes Massive Apoptosis, Exencephaly, and Early Embryonic Lethality in Homozygous Mice

Thioredoxin 2 (Trx-2) is a small redox protein containing the thioredoxin active site Trp-Cys-Gly-Pro-Cys that is localized to the mitochondria by a mitochondrial leader sequence and encoded by a nuclear gene (Trx-2). Trx-2 plays an important role in cell viability and the regulation of apoptosis in...

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Manylion Llyfryddiaeth

Cyhoeddwyd yn:	Mol Cell Biol
Prif Awduron:	Nonn, Larisa, Williams, Ryan R., Erickson, Robert P., Powis, Garth
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Taylor & Francis 2003
Pynciau:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140716/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12529397/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.3.916-922.2003
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