Targeted Mutagenesis of the Hira Gene Results in Gastrulation Defects and Patterning Abnormalities of Mesoendodermal Derivatives Prior to Early Embryonic Lethality

The Hira gene encodes a nuclear WD40 domain protein homologous to the yeast transcriptional corepressors Hir1p and Hir2p. Using targeted mutagenesis we demonstrate that Hira is essential for murine embryogenesis. Analysis of inbred 129Sv embryos carrying the null mutation revealed an initial require...

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Detalhes bibliográficos
Main Authors: Roberts, Catherine, Sutherland, Helen F., Farmer, Hannah, Kimber, Wendy, Halford, Stephanie, Carey, Alisoun, Brickman, Joshua M., Wynshaw-Boris, Anthony, Scambler, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133693/
https://ncbi.nlm.nih.gov/pubmed/11884616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.7.2318-2328.2002
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