Targeted Mutagenesis of the Hira Gene Results in Gastrulation Defects and Patterning Abnormalities of Mesoendodermal Derivatives Prior to Early Embryonic Lethality

The Hira gene encodes a nuclear WD40 domain protein homologous to the yeast transcriptional corepressors Hir1p and Hir2p. Using targeted mutagenesis we demonstrate that Hira is essential for murine embryogenesis. Analysis of inbred 129Sv embryos carrying the null mutation revealed an initial require...

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Principais autores:	Roberts, Catherine, Sutherland, Helen F., Farmer, Hannah, Kimber, Wendy, Halford, Stephanie, Carey, Alisoun, Brickman, Joshua M., Wynshaw-Boris, Anthony, Scambler, Peter J.
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis 2002
Assuntos:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133693/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11884616/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.7.2318-2328.2002
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