Targeted Mutagenesis of the Hira Gene Results in Gastrulation Defects and Patterning Abnormalities of Mesoendodermal Derivatives Prior to Early Embryonic Lethality

The Hira gene encodes a nuclear WD40 domain protein homologous to the yeast transcriptional corepressors Hir1p and Hir2p. Using targeted mutagenesis we demonstrate that Hira is essential for murine embryogenesis. Analysis of inbred 129Sv embryos carrying the null mutation revealed an initial require...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Roberts, Catherine, Sutherland, Helen F., Farmer, Hannah, Kimber, Wendy, Halford, Stephanie, Carey, Alisoun, Brickman, Joshua M., Wynshaw-Boris, Anthony, Scambler, Peter J.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 2002
Schlagworte:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133693/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11884616/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.7.2318-2328.2002
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