Targeted Mutagenesis of the Hira Gene Results in Gastrulation Defects and Patterning Abnormalities of Mesoendodermal Derivatives Prior to Early Embryonic Lethality

The Hira gene encodes a nuclear WD40 domain protein homologous to the yeast transcriptional corepressors Hir1p and Hir2p. Using targeted mutagenesis we demonstrate that Hira is essential for murine embryogenesis. Analysis of inbred 129Sv embryos carrying the null mutation revealed an initial require...

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Bibliographic Details
Main Authors: Roberts, Catherine, Sutherland, Helen F., Farmer, Hannah, Kimber, Wendy, Halford, Stephanie, Carey, Alisoun, Brickman, Joshua M., Wynshaw-Boris, Anthony, Scambler, Peter J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC133693/
https://ncbi.nlm.nih.gov/pubmed/11884616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.7.2318-2328.2002
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