Mcl-1 deficiency results in peri-implantation embryonic lethality

We disrupted the Mcl-1 locus in murine ES cells to determine the developmental roles of this Bcl-2 family member. Deletion of Mcl-1 resulted in peri-implantation embryonic lethality. Mcl-1(−/−) embryos do not implant in utero, but could be recovered at E3.5–4.0. Null blastocysts failed to hatch or a...

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Pubblicato in:	Genes Dev
Autori principali:	Rinkenberger, Julie L., Horning, Susan, Klocke, Barbara, Roth, Kevin, Korsmeyer, Stanley J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 2000
Soggetti:	Research Communication
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316347/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10640272/
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