Mcl-1 deficiency results in peri-implantation embryonic lethality
We disrupted the Mcl-1 locus in murine ES cells to determine the developmental roles of this Bcl-2 family member. Deletion of Mcl-1 resulted in peri-implantation embryonic lethality. Mcl-1(−/−) embryos do not implant in utero, but could be recovered at E3.5–4.0. Null blastocysts failed to hatch or a...
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| Publicat a: | Genes Dev |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2000
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316347/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10640272/ |
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