Association between DPYD c.1129-5923 C>G/hapB3 and severe toxicity to 5-fluorouracil-based chemotherapy in stage III colon cancer patients: NCCTG N0147 (Alliance)

Severe (grade≥3) adverse events (AEs) to 5-fluorouracil (5-FU)-based chemotherapy regimens can result in treatment delays or cessation, and, in extreme cases, life-threatening complications. Current genetic biomarkers for 5-FU toxicity prediction, however, account for only a small proportion of toxi...

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Detaylı Bibliyografya
Yayımlandı:Pharmacogenet Genomics
Asıl Yazarlar: Lee, Adam M., Shi, Qian, Alberts, Steven R., Sargent, Daniel J., Sinicrope, Frank A., Berenberg, Jeffrey L., Grothey, Axel, Polite, Blase, Chan, Emily, Gill, Sharlene, Kahlenberg, Morton S., Nair, Suresh G., Shields, Anthony F., Goldberg, Richard M., Diasio, Robert B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738010/
https://ncbi.nlm.nih.gov/pubmed/26658227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000197
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