Association between DPYD c.1129-5923 C>G/hapB3 and severe toxicity to 5-fluorouracil-based chemotherapy in stage III colon cancer patients: NCCTG N0147 (Alliance)

Severe (grade≥3) adverse events (AEs) to 5-fluorouracil (5-FU)-based chemotherapy regimens can result in treatment delays or cessation, and, in extreme cases, life-threatening complications. Current genetic biomarkers for 5-FU toxicity prediction, however, account for only a small proportion of toxi...

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Bibliografski detalji
Izdano u:Pharmacogenet Genomics
Glavni autori: Lee, Adam M., Shi, Qian, Alberts, Steven R., Sargent, Daniel J., Sinicrope, Frank A., Berenberg, Jeffrey L., Grothey, Axel, Polite, Blase, Chan, Emily, Gill, Sharlene, Kahlenberg, Morton S., Nair, Suresh G., Shields, Anthony F., Goldberg, Richard M., Diasio, Robert B.
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738010/
https://ncbi.nlm.nih.gov/pubmed/26658227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000197
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