Association between DPYD c.1129-5923 C>G/hapB3 and severe toxicity to 5-fluorouracil-based chemotherapy in stage III colon cancer patients: NCCTG N0147 (Alliance)

Severe (grade≥3) adverse events (AEs) to 5-fluorouracil (5-FU)-based chemotherapy regimens can result in treatment delays or cessation, and, in extreme cases, life-threatening complications. Current genetic biomarkers for 5-FU toxicity prediction, however, account for only a small proportion of toxi...

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Publicat a:Pharmacogenet Genomics
Autors principals: Lee, Adam M., Shi, Qian, Alberts, Steven R., Sargent, Daniel J., Sinicrope, Frank A., Berenberg, Jeffrey L., Grothey, Axel, Polite, Blase, Chan, Emily, Gill, Sharlene, Kahlenberg, Morton S., Nair, Suresh G., Shields, Anthony F., Goldberg, Richard M., Diasio, Robert B.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738010/
https://ncbi.nlm.nih.gov/pubmed/26658227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000197
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