Association between DPYD c.1129-5923 C>G/hapB3 and severe toxicity to 5-fluorouracil-based chemotherapy in stage III colon cancer patients: NCCTG N0147 (Alliance)

Severe (grade≥3) adverse events (AEs) to 5-fluorouracil (5-FU)-based chemotherapy regimens can result in treatment delays or cessation, and, in extreme cases, life-threatening complications. Current genetic biomarkers for 5-FU toxicity prediction, however, account for only a small proportion of toxi...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Pharmacogenet Genomics
Κύριοι συγγραφείς: Lee, Adam M., Shi, Qian, Alberts, Steven R., Sargent, Daniel J., Sinicrope, Frank A., Berenberg, Jeffrey L., Grothey, Axel, Polite, Blase, Chan, Emily, Gill, Sharlene, Kahlenberg, Morton S., Nair, Suresh G., Shields, Anthony F., Goldberg, Richard M., Diasio, Robert B.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2016
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738010/
https://ncbi.nlm.nih.gov/pubmed/26658227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000197
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