Sorivudine and 5-fluorouracil; a clinically significant drug-drug interaction due to inhibition of dihydropyrimidine dehydrogenase

Por Diasio, Robert B
Publicado em 1998

Human Respiration: A Programmed Course

Por Diasio, Robert B.
Publicado em 1969

Biological Psychiatry

Por Diasio, Robert B.
Publicado em 1969

Response to “A case of 5-FU related severe toxicity associated to the p.Y186C DPYD variant”

Por Offer, Steven M., Diasio, Robert B.
Publicado em 2013

Evidence for Conversion of 5-Fluorocytosine to 5-Fluorouracil in Humans: Possible Factor in 5-Fluorocytosine Clinical Toxicity

Por Diasio, Robert B., Lakings, Duane E., Bennett, John E.
Publicado em 1978

Drug metabolism and pancreatic cancer

Por Flores, John Paul E., Diasio, Robert B., Saif, Muhammad Wasif
Publicado no Ann Gastroenterol (2017)

Hypokalemia secondary to capecitabine: a hidden toxicity?

Por Saif, Muhammad Wasif, Fekrazad, Mohammad Houman, Ledbetter, Leslie, Diasio, Robert B
Publicado em 2007

A phase I dose-escalation study of edotecarin (J-107088) combined with infusional 5-fluorouracil and leucovorin in patients with advanced/metastatic solid tumors

Por Saif, Muhammad Wasif, Sellers, Sandra, Diasio, Robert B., Douillard, Jean-Yves
Publicado em 2010

Imatinib-induced hyperbilirubinemia with UGT1A1 (*28) promoter polymorphism: first case series in patients with gastrointestinal stromal tumor

Por Saif, Muhammad Wasif, Smith, Melissa Hennessey, Maloney, Antonia, Diasio, Robert B.
Publicado no Ann Gastroenterol (2016)

DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DPD) IN GI MALIGNANCIES: EXPERIENCE OF 4-YEARS

Por Saif, M. Wasif, Syrigos, Kostas, Mehra, Ranee, Mattison, Lori K., Diasio, Robert B
Publicado em 2007

Phenotypic profiling of DPYD variations relevant to 5-fluorouracil sensitivity using real-time cellular analysis and in vitro measurement of enzyme activity

Por Offer, Steven M., Wegner, Natalie J., Fossum, Croix, Wang, Kangsheng, Diasio, Robert B.
Publicado em 2013

Acquired factor VII deficiency following FOLFOX in a patient with colorectal cancer who was also DPD deficient

Por Saif, Muhammad Wasif, Wasif, Komal, Butler-Bowen, Harriette, Miller, Kenneth, Diasio, Robert B.
Publicado no Therap Adv Gastroenterol (2016)

Role of Matrix Metalloproteinases in Colorectal Carcinogenesis

Por Heslin, Martin J., Yan, Jieming, Johnson, Martin R., Weiss, Heidi, Diasio, Robert B., Urist, Marshall M.
Publicado em 2001

A DPYD variant (Y186C) in individuals of African ancestry associated with reduced DPD enzyme activity

Por Offer, Steven M., Lee, Adam M., Mattison, Lori K., Fossum, Croix, Wegner, Natalie J., Diasio, Robert B.
Publicado em 2013

A DPYD variant (Y186C) specific to individuals of African descent in a patient with life-threatening 5-FU toxicity: potential for an individualized medicine approach

Por Saif, M. Wasif, Lee, Adam M., Offer, Steven M., McConnell, Kathleen, Relias, Valerie, Diasio, Robert B.
Publicado em 2014

MicroRNAs miR-27a and miR-27b directly regulate liver dihydropyrimidine dehydrogenase expression through two conserved binding sites

Por Offer, Steven M., Butterfield, Gabriel L., Jerde, Calvin R., Fossum, Croix C., Wegner, Natalie J., Diasio, Robert B.
Publicado em 2014

Comparative functional analysis of DPYD variants of potential clinical relevance to dihydropyrimidine dehydrogenase activity

Por Offer, Steven M., Fossum, Croix C., Wegner, Natalie J., Stuflesser, Alexander J., Butterfield, Gabriel L., Diasio, Robert B.
Publicado em 2014

Association study of the let-7 miRNA-complementary site variant in the 3’ untranslated region of the KRAS gene in stage III colon cancer (NCCTG N0147 clinical trial)

Por Sha, Dan, Lee, Adam, Shi, Qian, Alberts, Steven R., Sargent, Daniel J., Sinicrope, Frank A., Diasio, Robert B.
Publicado em 2014

Prognostic Impact of Body Mass Index Stratified by Smoking Status in Patients With Esophageal Adenocarcinoma

Por Yoon, Harry H., Lewis, Mark A., Shi, Qian, Khan, Maliha, Cassivi, Stephen D., Diasio, Robert B., Sinicrope, Frank A.
Publicado em 2011

A Phase II Study of Modulated-Capecitabine and Docetaxel in Chemonaive Patients with Advanced Non-Small Cell Lung Cancer (NSCLC)

Por Bertino, Erin M., Bekaii-Saab, Tanios, Fernandez, Soledad, Diasio, Robert B., Karim, Nagla A., Otterson, Gregory A., Villalona-Calero, Miguel A.
Publicado em 2012