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A DPYD variant (Y186C) in individuals of African ancestry associated with reduced DPD enzyme activity
5-fluorouracil (5-FU) is used to treat many aggressive cancers, such as those of the colon, breast, and head & neck. The responses to 5-FU, both toxicity and efficacy, vary between racial groups, potentially due to variability in enzyme activity of dihydropyrimidine dehydrogenase (DPD, encoded b...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3821392/ https://ncbi.nlm.nih.gov/pubmed/23588312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2013.69 |
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