DPYD Variants as Predictors of 5-fluorouracil Toxicity in Adjuvant Colon Cancer Treatment (NCCTG N0147)

BACKGROUND: Previous studies have suggested the potential importance of three DPYD variants (DPYD*2A, D949V, and I560S) with increased 5-FU toxicity. Their individual associations, however, in 5-FU-based combination therapies, remain controversial and require further systematic study in a large pati...

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Detalhes bibliográficos
Publicado no:J Natl Cancer Inst
Main Authors: Lee, Adam M., Shi, Qian, Pavey, Emily, Alberts, Steven R., Sargent, Daniel J., Sinicrope, Frank A., Berenberg, Jeffrey L., Goldberg, Richard M., Diasio, Robert B.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271081/
https://ncbi.nlm.nih.gov/pubmed/25381393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/dju298
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