Reversible interconversion and maintenance of mammary epithelial cell characteristics by the ligand-regulated EGFR system

Epithelial cell plasticity is controlled by extracellular cues, but the underlying mechanisms remain to be fully understood. Epidermal growth factor (EGF) and amphiregulin (AREG) are high- and low-affinity ligands for EGF receptor (EGFR), respectively. EGFR signaling is known to promote epithelial-m...

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Published in:Sci Rep
Main Authors: Fukuda, Shinji, Nishida-Fukuda, Hisayo, Nanba, Daisuke, Nakashiro, Koh-ichi, Nakayama, Hironao, Kubota, Hiroyuki, Higashiyama, Shigeki
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4735799/
https://ncbi.nlm.nih.gov/pubmed/26831618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20209
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