Human Antigen R-mediated mRNA Stabilization Is Required for Ultraviolet B-induced Autoinduction of Amphiregulin in Keratinocytes

All members of the EGF family are produced as transmembrane precursors that are proteolytically processed into soluble forms by disintegrin and metalloproteinases (ADAMs) for autocrine/paracrine pathways. In turn, the ligand-activated EGF receptor (EGFR) induces the expression of EGF family members,...

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Main Authors: Nakayama, Hironao, Fukuda, Shinji, Matsushita, Natsuki, Nishida-Fukuda, Hisayo, Inoue, Hirofumi, Shirakata, Yuji, Hashimoto, Koji, Higashiyama, Shigeki
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624417/
https://ncbi.nlm.nih.gov/pubmed/23430747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.417527
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