Susceptibility to renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10.
Germ-line mutations of tumor suppressor genes confer strong predisposition to tumor formation. In the rat, a form of dominantly inherited renal carcinoma (RC) results in multiple chromophobe cell tumors that resemble the human disease, and heterozygous carriers (RC/+) are highly susceptible to envir...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1993
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47283/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8103600/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.17.8038 |
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