Transgenic rescue from embryonic lethality and renal carcinogenesis in the Eker rat model by introduction of a wild-type Tsc2 gene

We recently reported that a germ-line insertion in the rat homologue of the human tuberous sclerosis gene (TSC2) gives rise to dominantly inherited cancer in the Eker rat model. In this study, we constructed transgenic Eker rats with introduction of a wild-type Tsc2 gene to ascertain whether suppres...

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Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Kobayashi, Toshiyuki, Mitani, Hiroaki, Takahashi, Ri-ichi, Hirabayashi, Masumi, Ueda, Masatsugu, Tamura, Hiroshi, Hino, Okio
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1997
Предметы:	Biological Sciences
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20555/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9108092/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.8.3990
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