Tsc2 mutation rather than Tsc1 mutation dominantly causes a social deficit in a mouse model of tuberous sclerosis complex

Abstract Background Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that is associated with neurological symptoms, including autism spectrum disorder. Tuberous sclerosis complex is caused by pathogenic germline mutations of either the TSC1 or TSC2 gene, but somatic mutations were...

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Autori principali:	Hirofumi Kashii, Shinya Kasai, Atsushi Sato, Yoko Hagino, Yasumasa Nishito, Toshiyuki Kobayashi, Okio Hino, Masashi Mizuguchi, Kazutaka Ikeda
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2023-02-01
Serie:	Human Genomics
Soggetti:	Double mutations Pdlim2 Rapamycin Tsc1 Tsc2 Tuberous sclerosis complex
Accesso online:	https://doi.org/10.1186/s40246-023-00450-2
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