Transgenic rescue from embryonic lethality and renal carcinogenesis in the Eker rat model by introduction of a wild-type Tsc2 gene

We recently reported that a germ-line insertion in the rat homologue of the human tuberous sclerosis gene (TSC2) gives rise to dominantly inherited cancer in the Eker rat model. In this study, we constructed transgenic Eker rats with introduction of a wild-type Tsc2 gene to ascertain whether suppres...

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izdano v:	Proc Natl Acad Sci U S A
Principais autores:	Kobayashi, Toshiyuki, Mitani, Hiroaki, Takahashi, Ri-ichi, Hirabayashi, Masumi, Ueda, Masatsugu, Tamura, Hiroshi, Hino, Okio
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 1997
Teme:	Biological Sciences
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20555/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9108092/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.8.3990
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