Transgenic rescue from embryonic lethality and renal carcinogenesis in the Eker rat model by introduction of a wild-type Tsc2 gene

We recently reported that a germ-line insertion in the rat homologue of the human tuberous sclerosis gene (TSC2) gives rise to dominantly inherited cancer in the Eker rat model. In this study, we constructed transgenic Eker rats with introduction of a wild-type Tsc2 gene to ascertain whether suppres...

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Λεπτομέρειες βιβλιογραφικής εγγραφής

Εκδόθηκε σε:	Proc Natl Acad Sci U S A
Κύριοι συγγραφείς:	Kobayashi, Toshiyuki, Mitani, Hiroaki, Takahashi, Ri-ichi, Hirabayashi, Masumi, Ueda, Masatsugu, Tamura, Hiroshi, Hino, Okio
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	National Academy of Sciences 1997
Θέματα:	Biological Sciences
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20555/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9108092/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.8.3990
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