Susceptibility to renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10.

Germ-line mutations of tumor suppressor genes confer strong predisposition to tumor formation. In the rat, a form of dominantly inherited renal carcinoma (RC) results in multiple chromophobe cell tumors that resemble the human disease, and heterozygous carriers (RC/+) are highly susceptible to envir...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Yeung, R S, Buetow, K H, Testa, J R, Knudson, A G
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1993
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47283/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8103600/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.17.8038
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!