Susceptibility to renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10.

Germ-line mutations of tumor suppressor genes confer strong predisposition to tumor formation. In the rat, a form of dominantly inherited renal carcinoma (RC) results in multiple chromophobe cell tumors that resemble the human disease, and heterozygous carriers (RC/+) are highly susceptible to envir...

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Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Yeung, R S, Buetow, K H, Testa, J R, Knudson, A G
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1993
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47283/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8103600/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.17.8038
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