Using the BacMam Baculovirus System to Study Expression and Function of Recombinant Efflux Drug Transporters in Polarized Epithelial Cell Monolayers

The ATP-binding cassette (ABC) transporter superfamily includes several membrane-bound proteins that are critical to drug pharmacokinetics and disposition. Pharmacologic evaluation of these proteins in vitro remains a challenge. In this study, human ABC transporters were expressed in polarized epith...

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Publicado en:Drug Metab Dispos
Main Authors: Fung, King Leung, Kapoor, Khyati, Pixley, Jessica N., Talbert, Darrell J., Kwit, Alexandra D.T., Ambudkar, Suresh V., Gottesman, Michael M.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2016
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4727116/
https://ncbi.nlm.nih.gov/pubmed/26622052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.066506
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