BacMam production and crystal structure of nonglycosylated apo human furin at 1.89 Å resolution

Furin, also called proprotein convertase subtilisin/kexin 3 (PCSK3), is a calcium-dependent serine endoprotease that processes a wide variety of proproteins involved in cell function and homeostasis. Dysregulation of furin has been implicated in numerous disease states, including cancer and fibrosis...

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Vydáno v:Acta Crystallogr F Struct Biol Commun
Hlavní autoři: Pearce, Kenneth H., Overton, Laurie K., Gampe, Robert T., Barrett, George B., Taylor, J. David, McKee, David D., Campobasso, Nino, Nolte, Robert T., Reid, Robert A.
Médium: Artigo
Jazyk:Inglês
Vydáno: International Union of Crystallography 2019
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450522/
https://ncbi.nlm.nih.gov/pubmed/30950824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X19001419
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