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DNA supercoiling, a critical signal regulating the basal expression of the lac operon in Escherichia coli

Escherichia coli lac repressor (LacI) is a paradigmatic transcriptional factor that controls the expression of lacZYA in the lac operon. This tetrameric protein specifically binds to the O1, O2 and O3 operators of the lac operon and forms a DNA loop to repress transcription from the adjacent lac pro...

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Publicado en:Sci Rep
Autores principales: Fulcrand, Geraldine, Dages, Samantha, Zhi, Xiaoduo, Chapagain, Prem, Gerstman, Bernard S., Dunlap, David, Leng, Fenfei
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725879/
https://ncbi.nlm.nih.gov/pubmed/26763930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19243
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