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Dependence of Transcription-Coupled DNA Supercoiling on Promoter Strength in Escherichia coli Topoisomerase I Deficient Strains
Transcription by RNA polymerase can induce the formation of hypernegatively supercoiled DNA in vitro and in vivo. This phenomenon has been nicely explained by a “twin-supercoiled-domain” model of transcription where a positively supercoiled domain is generated ahead the RNA polymerase and a negative...
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| Published in: | Gene |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5992923/ https://ncbi.nlm.nih.gov/pubmed/23201416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2012.11.011 |
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