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Transcription-coupled DNA supercoiling in defined protein systems and in E. coli topA mutant strains

Transcription by RNA polymerases can stimulate (−) DNA supercoiling both in vitro and in E. coli topA strains. This phenomenon has been successfully explained by a "twin-supercoiled-domain" model of transcription in which (+) supercoils are produced in front of the transcribing RNA polymer...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:IUBMB Life
Hauptverfasser: Fulcrand, Geraldine, Zhi, Xiaoduo, Leng, Fenfei
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992920/
https://ncbi.nlm.nih.gov/pubmed/23757201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/iub.1179
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