Structural basis for m7G recognition and 2′-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I

RNAs with 5′-triphosphate (ppp) are detected in the cytoplasm principally by the innate immune receptor Retinoic Acid Inducible Gene-I (RIG-I), whose activation triggers a Type I IFN response. It is thought that self RNAs like mRNAs are not recognized by RIG-I because 5′ppp is capped by the addition...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Devarkar, Swapnil C., Wang, Chen, Miller, Matthew T., Ramanathan, Anand, Jiang, Fuguo, Khan, Abdul G., Patel, Smita S., Marcotrigiano, Joseph
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725518/
https://ncbi.nlm.nih.gov/pubmed/26733676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1515152113
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