The autoinhibitory CARD2-Hel2i Interface of RIG-I governs RNA selection

RIG-I (Retinoic Acid Inducible Gene-I) is a cytosolic innate immune receptor that detects atypical features in viral RNAs as foreign to initiate a Type I interferon signaling response. RIG-I is present in an autoinhibited state in the cytoplasm and activated by blunt-ended double-stranded (ds)RNAs c...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Ramanathan, Anand, Devarkar, Swapnil C., Jiang, Fuguo, Miller, Matthew T., Khan, Abdul G., Marcotrigiano, Joseph, Patel, Smita S.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737149/
https://ncbi.nlm.nih.gov/pubmed/26612866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1299
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