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RIG-I uses an ATPase-powered translocation-throttling mechanism for kinetic proofreading of RNAs and oligomerization
RIG-I has a remarkable ability to specifically select viral 5’ppp dsRNAs for activation from a pool of cytosolic self-RNAs. The ATPase activity of RIG-I plays a role in RNA discrimination and activation, but the underlying mechanism was unclear. Using transient state kinetics, we have elucidated the...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6434538/ https://ncbi.nlm.nih.gov/pubmed/30270105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.08.021 |
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