HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity

Retinoic acid inducible gene-I (RIG-I) ensures immune surveillance of viral RNAs bearing a 5’-triphosphate (5’ppp) moiety. Mutations in RIG-I (C268F and E373A) lead to impaired ATPase activity, thereby driving hyperactive signaling associated with autoimmune diseases. Here we report, using hydrogen/...

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Publicado no:Nat Commun
Main Authors: Zheng, Jie, Wang, Chen, Chang, Mi Ra, Devarkar, Swapnil C., Schweibenz, Brandon, Crynen, Gogce C., Garcia-Ordonez, Ruben D., Pascal, Bruce D., Novick, Scott J., Patel, Smita S., Marcotrigiano, Joseph, Griffin, Patrick R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6299088/
https://ncbi.nlm.nih.gov/pubmed/30560918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07780-z
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