Functional screen identifies kinases driving prostate cancer visceral and bone metastasis

Mutationally activated kinases play an important role in the progression and metastasis of many cancers. Despite numerous oncogenic alterations implicated in metastatic prostate cancer, mutations of kinases are rare. Several lines of evidence suggest that nonmutated kinases and their pathways are in...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Faltermeier, Claire M., Drake, Justin M., Clark, Peter M., Smith, Bryan A., Zong, Yang, Volpe, Carmen, Mathis, Colleen, Morrissey, Colm, Castor, Brandon, Huang, Jiaoti, Witte, Owen N.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720329/
https://ncbi.nlm.nih.gov/pubmed/26621741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521674112
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