Cross-activating c-Met/β1 integrin complex drives metastasis and invasive resistance in cancer

The molecular underpinnings of invasion, a hallmark of cancer, have been defined in terms of individual mediators but crucial interactions between these mediators remain undefined. In xenograft models and patient specimens, we identified a c-Met/β1 integrin complex that formed during significant inv...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Jahangiri, Arman, Nguyen, Alan, Chandra, Ankush, Sidorov, Maxim K., Yagnik, Garima, Rick, Jonathan, Han, Sung Won, Chen, William, Flanigan, Patrick M., Schneidman-Duhovny, Dina, Mascharak, Smita, De Lay, Michael, Imber, Brandon, Park, Catherine C., Matsumoto, Kunio, Lu, Kan, Bergers, Gabriele, Sali, Andrej, Weiss, William A., Aghi, Manish K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642678/
https://ncbi.nlm.nih.gov/pubmed/28973887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701821114
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