Negative epistasis and evolvability in TEM-1 β-lactamase – The thin line between an enzyme’s conformational freedom and disorder

Epistasis is a key factor in evolution, since it determines which combinations of mutations provide adaptive solutions and which mutational pathways towards these solutions are accessible by natural selection. There is growing evidence for the pervasiveness of sign epistasis – a complete reversion o...

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Publicado en:J Mol Biol
Main Authors: Dellus-Gur, Eynat, Elias, Mikael, Caselli, Emilia, Prati, Fabio, Salverda, Merijn L.M., de Visser, J. Arjan G.M., Fraser, James S., Tawfik, Dan S.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718737/
https://ncbi.nlm.nih.gov/pubmed/26004540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.05.011
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